Does Cotrimoxazole Interact with Amphotericin B?
CDI records a moderate classification for Cotrimoxazole and Amphotericin B. The stored summary is: Imidazoles may induce fungal resistance to amphotericin B. Combination therapy should be administered with caution, especially in immunocompromised patients. The mechanism involves induction of fungal resistance to amphotericin b. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Cotrimoxazole Class
- Azole Antifungal
- Amphotericin B Class
- Lipid-based Polyene Antifungal
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Induction of fungal resistance to amphotericin B
What To Tell Your Doctor or Pharmacist
If you are taking Cotrimoxazole and your doctor is considering prescribing Amphotericin B (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider