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Does Cotrimoxazole Interact with Flucytosine?

Cotrimoxazole and Flucytosine have a unknown drug interaction according to U.S. FDA drug labeling data. Synergism or antagonism between clotrimazole and flucytosine against C. albicans has not been reported. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Unknown
Cotrimoxazole Class
Azole Antifungal
Flucytosine Class
Nucleoside Analog Antifungal
Management
Consult your pharmacist
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Cotrimoxazole and your doctor is considering prescribing Flucytosine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Cotrimoxazole(Fungicure Solution)+💊 Flucytosine(Ancobon)

Severity & Interaction Details

ℹ️
unknown
Interaction documented — severity unclassified
The FDA label notes an interaction but the severity is not classified in our dataset.
Severity scale
MinorContra
On record
Yes
Drug A class
Azole Antifungal
Drug B class
Nucleoside Analog Antifungal
Source
NLP:clotrimazole

What this means in plain English

Synergism or antagonism between clotrimazole and flucytosine against C. albicans has not been reported.

About Cotrimoxazole and Flucytosine

Cotrimoxazole is an Azole Antifungal, while Flucytosine is a Nucleoside Analog Antifungal. You may recognize them by the brand names Dermatin and Ancobon. Cotrimoxazole is applied to the skin, whereas Flucytosine is taken by mouth. Flucytosine additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.