Does Cyclophosphamide Interact with Muscle Relaxants?
CDI records a major classification for Cyclophosphamide and Muscle Relaxants. The stored summary is: Cyclophosphamide causes marked and persistent inhibition of cholinesterase activity, which may result in prolonged apnea if used within 10 days of general anesthesia. The mechanism involves inhibition of cholinesterase activity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Cyclophosphamide Class
- Alkylating Drug
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of cholinesterase activity
What To Tell Your Doctor or Pharmacist
If you are taking Cyclophosphamide and your doctor is considering prescribing Muscle Relaxants (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider