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Does Cyclosporine Interact with Etoposide?

Cyclosporine and Etoposide have a major drug interaction according to U.S. FDA drug labeling data. High-dose cyclosporin A (concentrations >2000 ng/mL) increases etoposide exposure by 80% and decreases total body clearance by 38%, potentially increasing etoposide toxicity. The mechanism involves decreased etoposide clearance. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Cyclosporine Class
Calcineurin Inhibitor Immunosuppressant
Etoposide Class
Topoisomerase Inhibitor
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Cyclosporine and Etoposide occurs because decreased etoposide clearance. Clinically, this means high-dose cyclosporin a (concentrations >2000 ng/ml) increases etoposide exposure by 80% and decreases total body clearance by 38%, potentially increasing etoposide toxicity. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Cyclosporine and your doctor is considering prescribing Etoposide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Cyclosporine(Neoral)+💊 Etoposide(Etoposide)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Calcineurin Inhibitor Immunosuppressant
Drug B class
Topoisomerase Inhibitor
Source
NLP:etoposide

What this means in plain English

High-dose cyclosporin A (concentrations >2000 ng/mL) increases etoposide exposure by 80% and decreases total body clearance by 38%, potentially increasing etoposide toxicity.

What the FDA label says

"Decreased etoposide clearance"

📖 Source: NLP:etoposide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.