Does Cyclosporine Interact with Fenofibrate?
CDI records a major classification for Cyclosporine and Fenofibrate. The stored summary is: Risk of nephrotoxicity and deterioration of renal function due to decreased creatinine clearance. Requires careful benefit-risk assessment and renal function monitoring. The mechanism involves immunosuppressants produce nephrotoxicity; fenofibrate eliminated by renal excretion. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Cyclosporine Class
- Calcineurin Inhibitor Immunosuppressant
- Fenofibrate Class
- Peroxisome Proliferator Receptor alpha Agonist
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Immunosuppressants produce nephrotoxicity; fenofibrate eliminated by renal excretion
What To Tell Your Doctor or Pharmacist
If you are taking Cyclosporine and your doctor is considering prescribing Fenofibrate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider