Does Cyclosporine Interact with Methylprednisolone?
Cyclosporine and Methylprednisolone have a major drug interaction according to U.S. FDA drug labeling data. Mutual inhibition of metabolism occurs with concurrent use; convulsions have been reported with concurrent use of methylprednisolone and cyclosporin. The mechanism involves mutual inhibition of metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Cyclosporine Class
- Calcineurin Inhibitor Immunosuppressant
- Methylprednisolone Class
- Corticosteroid
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Cyclosporine and Methylprednisolone occurs because mutual inhibition of metabolism. Clinically, this means mutual inhibition of metabolism occurs with concurrent use; convulsions have been reported with concurrent use of methylprednisolone and cyclosporin. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Cyclosporine and your doctor is considering prescribing Methylprednisolone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider