Home›Methylprednisolone›Methylprednisolone + Amphotericin B

Does Methylprednisolone Interact with Amphotericin B?

Methylprednisolone and Amphotericin B have a major drug interaction according to U.S. FDA drug labeling data. Concomitant use with potassium-depleting agents increases hypokalemia risk. Cases of cardiac enlargement and congestive heart failure reported with concurrent amphotericin B and hydrocortisone. The mechanism involves potassium depletion. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Methylprednisolone Class
Corticosteroid
Amphotericin B Class
Lipid-based Polyene Antifungal
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Methylprednisolone and Amphotericin B occurs because potassium depletion. Clinically, this means concomitant use with potassium-depleting agents increases hypokalemia risk. cases of cardiac enlargement and congestive heart failure reported with concurrent amphotericin b and hydrocortisone. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Methylprednisolone and your doctor is considering prescribing Amphotericin B (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Methylprednisolone+💊 Amphotericin B(Amphotericin B)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Corticosteroid
Drug B class
Lipid-based Polyene Antifungal
Source
NLP:methylprednisolone

What this means in plain English

Concomitant use with potassium-depleting agents increases hypokalemia risk. Cases of cardiac enlargement and congestive heart failure reported with concurrent amphotericin B and hydrocortisone.

What the FDA label says

"Potassium depletion"

📖 Source: NLP:methylprednisolone

Share this result:XFacebookWhatsAppReddit
Add more drugs
Check Methylprednisolone and Amphotericin B against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.