Does Cyclosporine Interact with Metronidazole?
CDI records a moderate classification for Cyclosporine and Metronidazole. The stored summary is: CYP3A4 substrate whose plasma levels may increase with concomitant metronidazole use. Monitor plasma concentrations. The mechanism involves increased cyp3a4 substrate plasma levels. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Cyclosporine Class
- Calcineurin Inhibitor Immunosuppressant
- Metronidazole Class
- Nitroimidazole Antimicrobial
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased CYP3A4 substrate plasma levels
What To Tell Your Doctor or Pharmacist
If you are taking Cyclosporine and your doctor is considering prescribing Metronidazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider