Does Dronabinol Interact with Metronidazole?
CDI records a contraindicated classification for Dronabinol and Metronidazole. The stored summary is: Dronabinol oral solution contains alcohol which produces disulfiram-like reactions when co-administered with metronidazole. Discontinue metronidazole at least 14 days before starting dronabinol and do not administer within 7 days of completing treatment. The mechanism involves disulfiram-like reaction due to alcohol content in dronabinol oral solution. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
Evidence status
A current label comparison is not yet available for this record. The summary and severity are stored CDI information; they have not been independently validated on this page against the exact product label.
Confirm the medicine, formulation, route, and applicable warning with your pharmacist or prescriber. Independent clinical review has not been recorded.
- Stored CDI classification
- Contraindicated
- Dronabinol Class
- Cannabinoid
- Metronidazole Class
- Nitroimidazole Antimicrobial
- Management
- Confirm exact products with your pharmacist
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Disulfiram-like reaction due to alcohol content in dronabinol oral solution
What To Tell Your Doctor or Pharmacist
If you are taking Dronabinol and your doctor is considering prescribing Metronidazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider