Does Cyclosporine Interact with Modafinil?
Cyclosporine and Modafinil have a moderate drug interaction according to U.S. FDA drug labeling data. Blood levels of cyclosporine may be reduced when used with modafinil. Monitoring of circulating concentrations and dosage adjustment should be considered. The mechanism involves induction of cyp3a4/5 metabolic enzymes increasing clearance. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Cyclosporine Class
- Calcineurin Inhibitor Immunosuppressant
- Modafinil Class
- Sympathomimetic-like Agent
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Cyclosporine and Modafinil occurs because induction of cyp3a4/5 metabolic enzymes increasing clearance. Clinically, this means blood levels of cyclosporine may be reduced when used with modafinil. monitoring of circulating concentrations and dosage adjustment should be considered. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Cyclosporine and your doctor is considering prescribing Modafinil (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider