Modafinil has 22 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Lemborexant, Levonorgestrel/Ethinyl Estradiol And Ethinyl Estradiol, Lurasidone Hydrochloride. Patients taking Modafinil should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 22
- Contraindicated
- 1
- Major
- 4
- Moderate
- 17
Contraindicated (1)
- Modafinil + Lemborexant— Moderate CYP3A inducer that decreases lemborexant exposure, which may reduce DAYVIGO efficacy. Concomitant use should be…
Major (4)
- Modafinil + Levonorgestrel/Ethinyl Estradiol And Ethinyl Estradiol— Increases metabolism of contraceptive steroids, reducing contraceptive effectiveness and potentially resulting in uninte…
- Modafinil + Lurasidone Hydrochloride— Moderate CYP3A4 inducer decreases lurasidone exposure. Lurasidone dose should be increased.
- Modafinil + Macimorelin Acetate— Strong CYP3A4 inducer may reduce plasma macimorelin concentrations and lead to false positive test results. Discontinue …
- Modafinil + Medroxyprogesterone Acetate— Moderate CYP3A inducer may decrease medroxyprogesterone acetate concentrations and reduce contraceptive efficacy. Avoid …
Moderate (17)
- Modafinil + Axitinib— Moderate CYP3A4/5 inducer may reduce axitinib plasma exposure and should be avoided if possible.
- Modafinil + Clomipramine— Elimination may be prolonged by modafinil with resultant higher systemic exposure. Dose adjustment may be necessary when…
- Modafinil + Cyclosporine— Blood levels of cyclosporine may be reduced when used with modafinil. Monitoring of circulating concentrations and dosag…
- Modafinil + Diazepam— Elimination may be prolonged by modafinil with resultant higher systemic exposure. Dose adjustment may be necessary when…
- Modafinil + Esketamine Hydrochloride— Concomitant use may increase blood pressure. Closely monitor blood pressure with concomitant use.
- Modafinil + Ethinyl Estradiol— Effectiveness of steroidal contraceptives may be reduced when used with modafinil. Alternative or concomitant contracept…
- Modafinil + Ioflupane I-123— Binds to dopamine transporter with high affinity and may interfere with Ioflupane I-123 imaging results.
- Modafinil + Mao Inhibitors— Caution should be used when concomitantly administering MAO inhibitors and modafinil.
- Modafinil + Midazolam— Clearance may be increased by modafinil resulting in lower systemic exposure. Dosage adjustment should be considered whe…
- Modafinil + Monoamine Oxidase Inhibitors (Maois)— Caution should be used when concomitantly administering MAO inhibitors and modafinil.
- Modafinil + Omeprazole— Elimination may be prolonged by modafinil with resultant higher systemic exposure. Dose adjustment may be necessary when…
- Modafinil + Oral Contraceptives— Effectiveness of steroidal contraceptives may be reduced when used with modafinil. Alternative or concomitant contracept…
- Modafinil + Phenytoin— Elimination may be prolonged by modafinil with resultant higher systemic exposure. Dose adjustment may be necessary when…
- Modafinil + Propranolol— Elimination may be prolonged by modafinil with resultant higher systemic exposure. Dose adjustment may be necessary when…
- Modafinil + Selective Serotonin Reuptake Inhibitors (Ssri)— Levels may be increased in CYP2D6-deficient individuals due to modafinil's CYP2C19 inhibition affecting ancillary elimin…
- Modafinil + Triazolam— Clearance may be increased by modafinil resulting in lower systemic exposure. Dosage adjustment should be considered whe…
- Modafinil + Warfarin— More frequent monitoring of prothrombin times/INR should be considered whenever modafinil is coadministered with warfari…