Cyp3a Inducers + Avutometinib Potassium And Defactinib Hydrochloride Interaction

Majorinteraction on record

Description

Concomitant use decreases defactinib exposure, which may reduce the effectiveness of the drug combination. Avoid concomitant use.

Mechanism

Defactinib is a CYP3A4 substrate; induction decreases exposure

Source: NLP:avutometinib potassium and defactinib hydrochloride

Related drug profiles

All Cyp3a Inducers interactions →All Avutometinib Potassium And Defactinib Hydrochloride interactions →
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