Does Cyp3a Inducers Interact with Crinecerfont?
Moderate interaction. Concomitant use decreases crinecerfont exposure, which may reduce efficacy. Requires 2-fold increase in morning and evening dosage.
Source & how this summary was prepared
This interaction summary was extracted from FDA drug labeling through openFDA, using automated processing and AI assistance. NIH/NLM RxNorm helps organize drug names.
Read the saved source label on DailyMed →
A separate current-label comparison has not been recorded for this page. Read about our extraction process.
- Interaction classification
- Moderate
- Crinecerfont Class
- Corticotropin-releasing Factor Type 1 Receptor Antagonist
- Management
- Confirm exact products with your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How this interaction works
CRENESSITY is a CYP3A4 substrate; inducers decrease its exposure
What To Tell Your Doctor or Pharmacist
If you are taking Cyp3a Inducers and your doctor is considering prescribing Crinecerfont (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider