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Does Cyp3a Inhibitors Moderate And Strong Interact with Valsartan And Hydrochlorothiazide?

Cyp3a Inhibitors Moderate And Strong and Valsartan And Hydrochlorothiazide have a moderate drug interaction according to U.S. FDA drug labeling data. Coadministration with CYP3A inhibitors increases systemic exposure to amlodipine and may require dose reduction. Monitor for hypotension and edema. The mechanism involves cyp3a inhibition increases amlodipine systemic exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Valsartan And Hydrochlorothiazide Class
Angiotensin 2 Receptor Blocker
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Cyp3a Inhibitors Moderate And Strong and Valsartan And Hydrochlorothiazide occurs because cyp3a inhibition increases amlodipine systemic exposure. Clinically, this means coadministration with cyp3a inhibitors increases systemic exposure to amlodipine and may require dose reduction. monitor for hypotension and edema. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Cyp3a Inhibitors Moderate And Strong and your doctor is considering prescribing Valsartan And Hydrochlorothiazide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Cyp3a Inhibitors Moderate And Strong+💊 Valsartan And Hydrochlorothiazide(Valsartan And Hydrochlorothiazide)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Angiotensin 2 Receptor Blocker
Source
NLP:amlodipine,valsartan and hydrochlorothiazide

What this means in plain English

Coadministration with CYP3A inhibitors increases systemic exposure to amlodipine and may require dose reduction. Monitor for hypotension and edema.

What the FDA label says

"CYP3A inhibition increases amlodipine systemic exposure"

📖 Source: NLP:amlodipine,valsartan and hydrochlorothiazide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.