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Does Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide Interact with Nifedipine?

Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide and Nifedipine have a unknown drug interaction according to U.S. FDA drug labeling data. Calcium channel blockers: e.g., amlodipine, diltiazem, felodipine, nifedipine, verapamil ↑ calcium channel blockers Clinical monitoring is recommended for co-administration with calcium channel blockers metabolized by CYP3A. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Unknown
Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide Class
Cytochrome P450 3A Inhibitor
Nifedipine Class
Dihydropyridine Calcium Channel Blocker
Management
Consult your pharmacist
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide and your doctor is considering prescribing Nifedipine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide(Symtuza)+💊 Nifedipine(Procardia)

Severity & Interaction Details

ℹ️
unknown
Interaction documented — severity unclassified
The FDA label notes an interaction but the severity is not classified in our dataset.
Severity scale
MinorContra
On record
Yes
Drug A class
Cytochrome P450 3A Inhibitor
Drug B class
Dihydropyridine Calcium Channel Blocker
Source
FDA drug label - darunavir, cobicistat, emtricitabine, and tenofovir alafenamide

What this means in plain English

Calcium channel blockers: e.g., amlodipine, diltiazem, felodipine, nifedipine, verapamil ↑ calcium channel blockers Clinical monitoring is recommended for co-administration with calcium channel blockers metabolized by CYP3A.

About Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide and Nifedipine

Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide is a Cytochrome P450 3A Inhibitor, while Nifedipine is a Dihydropyridine Calcium Channel Blocker. You may recognize them by the brand names Symtuza and Procardia. Both medications are taken by mouth. Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.