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Does Desipramine Interact with Alprazolam?

Desipramine and Alprazolam have a moderate drug interaction according to U.S. FDA drug labeling data. Steady state plasma concentrations of desipramine can increase by approximately 20% when coadministered with alprazolam up to 4 mg/day. Clinical significance unknown. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Moderate
Alprazolam Class: Benzodiazepine
Management: Monitor for effects
Data Source: U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Desipramine and your doctor is considering prescribing Alprazolam (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask whether any dosage adjustments are needed
Never stop or change either medication without first consulting your healthcare provider

💊 Desipramine(Norpramin)+💊 Alprazolam(Xanax)

Severity & Interaction Details

🟡

moderate

Be aware — moderate interaction

Documented interaction with manageable risk. May require dose adjustment or monitoring.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

Benzodiazepine

Source

NLP:alprazolam

What this means in plain English

Steady state plasma concentrations of desipramine can increase by approximately 20% when coadministered with alprazolam up to 4 mg/day. Clinical significance unknown.

About Desipramine and Alprazolam

Alprazolam is a Benzodiazepine. You may recognize them by the brand names Norpramin and Xanax. Alprazolam is taken by mouth. Alprazolam additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.