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Does Itraconazole Interact with Alprazolam?

Itraconazole and Alprazolam have a contraindicated drug interaction according to U.S. FDA drug labeling data. Strong CYP3A inhibitor is contraindicated with alprazolam due to profound effect on clearance, resulting in increased concentrations. The mechanism involves strong cyp3a inhibition reduces alprazolam clearance. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Itraconazole Class
Azole Antifungal
Alprazolam Class
Benzodiazepine
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Itraconazole and Alprazolam occurs because strong cyp3a inhibition reduces alprazolam clearance. Clinically, this means strong cyp3a inhibitor is contraindicated with alprazolam due to profound effect on clearance, resulting in increased concentrations. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Itraconazole and your doctor is considering prescribing Alprazolam (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Itraconazole+💊 Alprazolam

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Azole Antifungal
Drug B class
Benzodiazepine
Source
NLP:alprazolam

What this means in plain English

Strong CYP3A inhibitor is contraindicated with alprazolam due to profound effect on clearance, resulting in increased concentrations.

What the FDA label says

"Strong CYP3A inhibition reduces alprazolam clearance"

📖 Source: NLP:alprazolam

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.