Desipramine + Bupropion Hydrochloride Interaction

Majorinteraction on record

Description

Bupropion increased desipramine Cmax, AUC, and t1/2 by approximately 2-, 5-, and 2-fold, respectively; effect persisted for at least 7 days after last bupropion dose.

Mechanism

CYP2D6 isoenzyme inhibition

Source: NLP:bupropion hydrochloride