Desipramine + Desvenlafaxine Interaction
Moderateinteraction on record
Description
Desvenlafaxine increases desipramine levels. Reduce dose by up to one-half with 400 mg desvenlafaxine; no adjustment needed with 100 mg or lower.
Mechanism
Desvenlafaxine inhibits CYP2D6 metabolism of desipramine
Source: NLP:desvenlafaxine