Desipramine + Terbinafine Interaction

Moderateinteraction on record

Description

Terbinafine inhibits CYP450 2D6, resulting in 2-fold increase in Cmax and 5-fold increase in AUC of desipramine. Effects persist up to 4 weeks after discontinuation. Monitor and may require dose reduction.

Mechanism

CYP450 2D6 inhibition

Source: NLP:terbinafine