Desipramine + Terbinafine Hydrochloride Interaction

Moderateinteraction on record

Description

Terbinafine inhibits CYP450 2D6 metabolism, resulting in 2-fold increase in Cmax and 5-fold increase in AUC. Effects persist for 4 weeks after discontinuation. Careful monitoring and dose reduction may be required.

Mechanism

CYP450 2D6 inhibition

Source: NLP:terbinafine hydrochloride