Does Dexlansoprazole Interact with Saquinavir?
CDI records a major classification for Dexlansoprazole and Saquinavir. The stored summary is: Increased exposure of saquinavir when used concomitantly with dexlansoprazole may increase toxicity of the antiretroviral drug. The mechanism involves ppi effect on saquinavir metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Dexlansoprazole Class
- Proton Pump Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
PPI effect on saquinavir metabolism
What To Tell Your Doctor or Pharmacist
If you are taking Dexlansoprazole and your doctor is considering prescribing Saquinavir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider