Dexlansoprazole has 21 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Emtricitabine, Rilpivirine And Tenofovir Disoproxil Fumarate, Emtricitabine, Rilpivirine Hydrochloride, And Tenofovir Alafenamide, Emtricitabine, Rilpivirine, Tenofovir Disoproxil Fumarate. Patients taking Dexlansoprazole should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 21
- Contraindicated
- 4
- Major
- 5
- Moderate
- 10
Contraindicated (4)
- Dexlansoprazole + Emtricitabine, Rilpivirine And Tenofovir Disoproxil Fumarate— Proton Pump Inhibitors: e.g., dexlansoprazole esomeprazole lansoprazole omeprazole pantoprazole rabeprazole ↓ RPV Coadmi…
- Dexlansoprazole + Emtricitabine, Rilpivirine Hydrochloride, And Tenofovir Alafenamide— Proton Pump Inhibitors: e.g., dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole ↓ RPV C…
- Dexlansoprazole + Emtricitabine, Rilpivirine, Tenofovir Disoproxil Fumarate— Proton Pump Inhibitors: e.g., dexlansoprazole esomeprazole lansoprazole omeprazole pantoprazole rabeprazole ↓ RPV Coadmi…
- Dexlansoprazole + Rilpivirine— Concomitant use with dexlansoprazole is contraindicated. Decreased exposure of rilpivirine may reduce antiviral effect a…
Major (5)
- Dexlansoprazole + Atazanavir— Decreased exposure of atazanavir when used concomitantly with dexlansoprazole may reduce antiviral effect and promote de…
- Dexlansoprazole + Methotrexate— Concomitant use may elevate and prolong serum concentrations of methotrexate and hydroxymethotrexate, possibly leading t…
- Dexlansoprazole + Nelfinavir— Decreased exposure of some antiretroviral drugs (e.g., rilpivirine, atazanavir, and nelfinavir) when used concomitantly …
- Dexlansoprazole + Saquinavir— Increased exposure of saquinavir when used concomitantly with dexlansoprazole may increase toxicity of the antiretrovira…
- Dexlansoprazole + Warfarin— Increased INR and prothrombin time may lead to abnormal bleeding and even death. Monitor INR and prothrombin time; dose …
Moderate (10)
- Dexlansoprazole + Clopidogrel— CYP2C19 inhibitor with less effect on clopidogrel antiplatelet activity compared to omeprazole or esomeprazole.
- Dexlansoprazole + Clopidogrel Bisulfate— CYP2C19 inhibitor with less effect on clopidogrel antiplatelet activity compared to omeprazole or esomeprazole.
- Dexlansoprazole + Dasatinib— Dexlansoprazole can reduce the absorption of dasatinib due to its effect on gastric pH.
- Dexlansoprazole + Digoxin— Potential for increased exposure of digoxin. Monitor digoxin concentrations; dose adjustment may be needed to maintain t…
- Dexlansoprazole + Erlotinib— Dexlansoprazole can reduce the absorption of erlotinib due to its effect on gastric pH.
- Dexlansoprazole + Iron Salts— Dexlansoprazole can reduce the absorption of iron salts due to its effect on gastric pH.
- Dexlansoprazole + Itraconazole— Dexlansoprazole can reduce the absorption of itraconazole due to its effect on gastric pH.
- Dexlansoprazole + Ketoconazole— Dexlansoprazole can reduce the absorption of ketoconazole due to its effect on gastric pH.
- Dexlansoprazole + Mycophenolate Mofetil— Dexlansoprazole can reduce the absorption of mycophenolate mofetil due to its effect on gastric pH.
- Dexlansoprazole + Nilotinib— Dexlansoprazole can reduce the absorption of nilotinib due to its effect on gastric pH.