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Does Didanosine And Stavudine Interact with Hydroxyurea?

Didanosine And Stavudine and Hydroxyurea have a contraindicated drug interaction according to U.S. FDA drug labeling data. Avoid this combination. Fatal hepatic events and severe peripheral neuropathy reported most often with hydroxyurea, didanosine, and stavudine combination in HIV patients. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Hydroxyurea Class
Antimetabolite
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Didanosine And Stavudine and your doctor is considering prescribing Hydroxyurea (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Didanosine And Stavudine+💊 Hydroxyurea(Hydrea)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Antimetabolite
Source
NLP:hydroxyurea

What this means in plain English

Avoid this combination. Fatal hepatic events and severe peripheral neuropathy reported most often with hydroxyurea, didanosine, and stavudine combination in HIV patients.

About Didanosine And Stavudine and Hydroxyurea

Hydroxyurea is an Antimetabolite. Hydroxyurea is also sold under the brand name Hydrea. Hydroxyurea is taken by mouth. Hydroxyurea additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.