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Does Digoxin Interact with Adenosine?

Digoxin and Adenosine have a major drug interaction according to U.S. FDA drug labeling data. Rarely associated with ventricular fibrillation when combined with adenosine injection. Use with caution due to potential additive depressant effects on SA and AV nodes. The mechanism involves additive or synergistic depressant effects on the sa and av nodes. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Digoxin Class
Cardiac Glycoside
Adenosine Class
Adenosine Receptor Agonist
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Digoxin and Adenosine occurs because additive or synergistic depressant effects on the sa and av nodes. Clinically, this means rarely associated with ventricular fibrillation when combined with adenosine injection. use with caution due to potential additive depressant effects on sa and av nodes. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Digoxin and your doctor is considering prescribing Adenosine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Digoxin(Digoxin)+💊 Adenosine(Adenosine)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Cardiac Glycoside
Drug B class
Adenosine Receptor Agonist
Source
NLP:adenosine

What this means in plain English

Rarely associated with ventricular fibrillation when combined with adenosine injection. Use with caution due to potential additive depressant effects on SA and AV nodes.

What the FDA label says

"Additive or synergistic depressant effects on the SA and AV nodes"

📖 Source: NLP:adenosine

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.