Does Digoxin Interact with Dexlansoprazole?
CDI records a moderate classification for Digoxin and Dexlansoprazole. The stored summary is: Potential for increased exposure of digoxin. Monitor digoxin concentrations; dose adjustment may be needed to maintain therapeutic levels. The mechanism involves increased digoxin absorption due to elevated gastric ph. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Digoxin Class
- Cardiac Glycoside
- Dexlansoprazole Class
- Proton Pump Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased digoxin absorption due to elevated gastric pH
What To Tell Your Doctor or Pharmacist
If you are taking Digoxin and your doctor is considering prescribing Dexlansoprazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider