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Does Digoxin Interact with Nitrendipine?

Digoxin and Nitrendipine have a major drug interaction according to U.S. FDA drug labeling data. Increases digoxin serum concentration by 57% and AUC by 15%. Requires dose reduction of 30-50% and monitoring. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Digoxin Class
Cardiac Glycoside
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Digoxin and your doctor is considering prescribing Nitrendipine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Digoxin(Digoxin)+💊 Nitrendipine

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Cardiac Glycoside
Drug B class
—
Source
NLP:digoxin

What this means in plain English

Increases digoxin serum concentration by 57% and AUC by 15%. Requires dose reduction of 30-50% and monitoring.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.