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Does Digoxin Interact with Risperidone?

Digoxin and Risperidone have a minor drug interaction according to U.S. FDA drug labeling data. Risperidone does not show clinically relevant effect on digoxin pharmacokinetics. Dose adjustment for digoxin not recommended. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Digoxin Class
Cardiac Glycoside
Risperidone Class
Atypical Antipsychotic
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Digoxin and your doctor is considering prescribing Risperidone (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Digoxin(Digox)+💊 Risperidone(Risperdal)

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
Cardiac Glycoside
Drug B class
Atypical Antipsychotic
Source
NLP:risperidone

What this means in plain English

Risperidone does not show clinically relevant effect on digoxin pharmacokinetics. Dose adjustment for digoxin not recommended.

About Digoxin and Risperidone

Digoxin is a Cardiac Glycoside, while Risperidone is an Atypical Antipsychotic. You may recognize them by the brand names Lanoxin and Risperdal. Both medications are taken by mouth. Risperidone additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.