Diltiazem Hydrochloride Extended Release Tablets + Ivabradine Interaction
Contraindicatedinteraction on record
Description
Diltiazem increases exposure to ivabradine and may exacerbate bradycardia and conduction disturbances. Concomitant use should be avoided.
Mechanism
Increased ivabradine exposure via CYP450 3A4 inhibition
Source: NLP:diltiazem hydrochloride extended-release tablets