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Does Dimethyl Fumarate Interact with Diroximel Fumarate?

Dimethyl Fumarate and Diroximel Fumarate have a contraindicated drug interaction according to U.S. FDA drug labeling data. VUMERITY (diroximel fumarate) is contraindicated in patients currently taking dimethyl fumarate, which is also metabolized to monomethyl fumarate. VUMERITY may be initiated the day following discontinuation of dimethyl fumarate. The mechanism involves both drugs are metabolized to monomethyl fumarate. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Dimethyl Fumarate and Diroximel Fumarate occurs because both drugs are metabolized to monomethyl fumarate. Clinically, this means vumerity (diroximel fumarate) is contraindicated in patients currently taking dimethyl fumarate, which is also metabolized to monomethyl fumarate. vumerity may be initiated the day following discontinuation of dimethyl fumarate. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Dimethyl Fumarate and your doctor is considering prescribing Diroximel Fumarate (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Dimethyl Fumarate+💊 Diroximel Fumarate(Vumerity)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:diroximel fumarate

What this means in plain English

VUMERITY (diroximel fumarate) is contraindicated in patients currently taking dimethyl fumarate, which is also metabolized to monomethyl fumarate. VUMERITY may be initiated the day following discontinuation of dimethyl fumarate.

What the FDA label says

"Both drugs are metabolized to monomethyl fumarate"

📖 Source: NLP:diroximel fumarate

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.