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Does Disopyramide Interact with Atenolol And Chlorthalidone?

Disopyramide and Atenolol And Chlorthalidone have a contraindicated drug interaction according to U.S. FDA drug labeling data. Associated with severe bradycardia, asystole, and heart failure when combined with beta-blockers due to potent negative inotropic and chronotropic effects. The mechanism involves additive negative inotropic and chronotropic effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Atenolol And Chlorthalidone Class
beta-Adrenergic Blocker
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Disopyramide and Atenolol And Chlorthalidone occurs because additive negative inotropic and chronotropic effects. Clinically, this means associated with severe bradycardia, asystole, and heart failure when combined with beta-blockers due to potent negative inotropic and chronotropic effects. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Disopyramide and your doctor is considering prescribing Atenolol And Chlorthalidone (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Disopyramide+💊 Atenolol And Chlorthalidone(Tenoretic)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
beta-Adrenergic Blocker
Source
NLP:atenolol and chlorthalidone

What this means in plain English

Associated with severe bradycardia, asystole, and heart failure when combined with beta-blockers due to potent negative inotropic and chronotropic effects.

What the FDA label says

"Additive negative inotropic and chronotropic effects"

📖 Source: NLP:atenolol and chlorthalidone

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.