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Does Disulfiram Interact with Tinidazole?

Disulfiram and Tinidazole have a contraindicated drug interaction according to U.S. FDA drug labeling data. Tinidazole should not be given to patients who have taken disulfiram within the last two weeks due to risk of psychotic reactions. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Contraindicated
Disulfiram Class: Aldehyde Dehydrogenase Inhibitor
Tinidazole Class: Nitroimidazole Antimicrobial
Management: Do not take together
Data Source: U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Disulfiram and your doctor is considering prescribing Tinidazole (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask about alternative medications that do not interact with your current regimen
Ask how frequently you should be monitored while these are co-prescribed
Never stop or change either medication without first consulting your healthcare provider

💊 Disulfiram(Antabuse)+💊 Tinidazole(Tindamax)

Severity & Interaction Details

⛔

contraindicated

Avoid this combination

FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.

Severity scale

MinorContra

On record

Yes

Drug A class

Aldehyde Dehydrogenase Inhibitor

Drug B class

Nitroimidazole Antimicrobial

Source

NLP:tinidazole

What this means in plain English

Tinidazole should not be given to patients who have taken disulfiram within the last two weeks due to risk of psychotic reactions.

About Disulfiram and Tinidazole

Disulfiram is an Aldehyde Dehydrogenase Inhibitor, while Tinidazole is a Nitroimidazole Antimicrobial. You may recognize them by the brand names Antabuse and Tindamax. Both medications are taken by mouth. Both Disulfiram and Tinidazole carry an FDA boxed warning — the agency's most serious safety designation.

Recent research & FDA safety updates

Live

Auto-aggregated from PubMed E-utilities and FDA safety data.

PubMed

In vitro, in vivo, and anticytotoxic effects of silver nanoparticles green synthesized by Astragalus baba-alliar against Giardia lamblia infection.about Tinidazole · 2026-06

PubMed

Computational fluid dynamics and machine learning modeling of drug delivery by hydroxypropyl methylcellulose.about Tinidazole · 2026-05

PubMed

Supply Chain Vulnerabilities in First-Line Treatments for Sexually Transmitted Infections: Implications for U.S. Public Health Preparedness.about Tinidazole · 2026-05

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.