Does Tinidazole Interact with Oral Anticoagulants?
CDI records a major classification for Tinidazole and Oral Anticoagulants. The stored summary is: Tinidazole may enhance the effect of coumarin anticoagulants, resulting in prolongation of prothrombin time. Dosage adjustment may be needed during tinidazole co-administration and up to 8 days after discontinuation. The mechanism involves enhancement of anticoagulant effect. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Tinidazole Class
- Nitroimidazole Antimicrobial
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Enhancement of anticoagulant effect
What To Tell Your Doctor or Pharmacist
If you are taking Tinidazole and your doctor is considering prescribing Oral Anticoagulants (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider