Does Divalproex Sodium Interact with Primidone?
CDI records a major classification for Divalproex Sodium and Primidone. The stored summary is: Enzyme-inducing drug that can double valproate clearance. Increased monitoring of valproate and primidone concentrations and dosage adjustment indicated. The mechanism involves hepatic enzyme induction increasing glucuronidation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Hepatic enzyme induction increasing glucuronidation
What To Tell Your Doctor or Pharmacist
If you are taking Divalproex Sodium and your doctor is considering prescribing Primidone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider