Does Dolutegravir Sodium Interact with Etravirine?
CDI records a major classification for Dolutegravir Sodium and Etravirine. The stored summary is: Etravirine significantly reduces plasma concentrations of dolutegravir, reducing therapeutic effect; coadministration with lopinavir/ritonavir, darunavir/ritonavir, or atazanavir/ritonavir may mitigate this effect. The mechanism involves enzyme induction reducing dolutegravir exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Etravirine Class
- Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Enzyme induction reducing dolutegravir exposure
What To Tell Your Doctor or Pharmacist
If you are taking Dolutegravir Sodium and your doctor is considering prescribing Etravirine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider