Duvelisib + Sensitive Cyp3a Substrates Interaction
Moderateinteraction on record
Description
COPIKTRA increases AUC of sensitive CYP3A4 substrates, which may increase the risk of toxicities. Monitor for signs of toxicities and consider reducing substrate dose.
Mechanism
COPIKTRA inhibits CYP3A4, increasing substrate exposure
Source: NLP:duvelisib