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Does Efavirenz Interact with Elbasvir And Grazoprevir?

Efavirenz and Elbasvir And Grazoprevir have a contraindicated drug interaction according to U.S. FDA drug labeling data. Co-administration with efavirenz is contraindicated as it is a strong CYP3A inducer that may decrease elbasvir and grazoprevir plasma concentrations, leading to reduced therapeutic effect. The mechanism involves cyp3a induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Efavirenz Class
Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
Elbasvir And Grazoprevir Class
Hepatitis C Virus NS5A Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Efavirenz and Elbasvir And Grazoprevir occurs because cyp3a induction. Clinically, this means co-administration with efavirenz is contraindicated as it is a strong cyp3a inducer that may decrease elbasvir and grazoprevir plasma concentrations, leading to reduced therapeutic effect. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Efavirenz and your doctor is considering prescribing Elbasvir And Grazoprevir (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Efavirenz(Efavirenz)+💊 Elbasvir And Grazoprevir(Zepatier)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
Drug B class
Hepatitis C Virus NS5A Inhibitor
Source
NLP:elbasvir and grazoprevir

What this means in plain English

Co-administration with efavirenz is contraindicated as it is a strong CYP3A inducer that may decrease elbasvir and grazoprevir plasma concentrations, leading to reduced therapeutic effect.

What the FDA label says

"CYP3A induction"

📖 Source: NLP:elbasvir and grazoprevir

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.