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Does Empagliflozin Interact with Lithium?

CDI records a moderate classification for Empagliflozin and Lithium. The stored summary is: Concomitant use may decrease serum lithium concentrations. Monitor lithium levels more frequently during initiation and dosage changes. The mechanism involves sglt2 inhibitor effect on lithium clearance. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Severity
Moderate
Empagliflozin Class
Sodium-Glucose Cotransporter 2 Inhibitor
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

Recorded Mechanism

SGLT2 inhibitor effect on lithium clearance

What To Tell Your Doctor or Pharmacist

If you are taking Empagliflozin and your doctor is considering prescribing Lithium (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Empagliflozin(Jardiance)+💊 Lithium(Lithium)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Sodium-Glucose Cotransporter 2 Inhibitor
Drug B class
—
Source
NLP:empagliflozin

What this means in plain English

Concomitant use may decrease serum lithium concentrations. Monitor lithium levels more frequently during initiation and dosage changes.

About Empagliflozin and Lithium

Empagliflozin is a Sodium-Glucose Cotransporter 2 Inhibitor. Empagliflozin is also sold under the brand name Jardiance. Lithium additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: NLP:empagliflozin

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.

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