Does Emtricitabine Rilpivirine Hydrochloride And Tenofovir Alafen Interact with Anakinra?
Emtricitabine Rilpivirine Hydrochloride And Tenofovir Alafen and Anakinra have a major drug interaction according to U.S. FDA drug labeling data. Use of RPV with H2-receptor antagonists requires staggered administration to avoid decreased plasma concentrations of RPV and loss of virologic response. The mechanism involves drugs that increase gastric ph decrease rpv absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Emtricitabine Rilpivirine Hydrochloride And Tenofovir Alafen Class
- Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor
- Anakinra Class
- Interleukin-1 Receptor Antagonist
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Emtricitabine Rilpivirine Hydrochloride And Tenofovir Alafen and Anakinra occurs because drugs that increase gastric ph decrease rpv absorption. Clinically, this means use of rpv with h2-receptor antagonists requires staggered administration to avoid decreased plasma concentrations of rpv and loss of virologic response. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Emtricitabine Rilpivirine Hydrochloride And Tenofovir Alafen and your doctor is considering prescribing Anakinra (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider