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Does Epinephrine Interact with Liothyronine Sodium?

Epinephrine and Liothyronine Sodium have a major drug interaction according to U.S. FDA drug labeling data. Thyroid hormones increase adrenergic effect of catecholamines. May increase risk of precipitating coronary insufficiency, especially in patients with coronary artery disease. The mechanism involves increased adrenergic effect of catecholamines. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Epinephrine Class
alpha-Adrenergic Agonist
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Epinephrine and Liothyronine Sodium occurs because increased adrenergic effect of catecholamines. Clinically, this means thyroid hormones increase adrenergic effect of catecholamines. may increase risk of precipitating coronary insufficiency, especially in patients with coronary artery disease. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Epinephrine and your doctor is considering prescribing Liothyronine Sodium (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Epinephrine(Adrenalin)+💊 Liothyronine Sodium(Liothyronine Sodium)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
alpha-Adrenergic Agonist
Drug B class
—
Source
NLP:liothyronine sodium

What this means in plain English

Thyroid hormones increase adrenergic effect of catecholamines. May increase risk of precipitating coronary insufficiency, especially in patients with coronary artery disease.

What the FDA label says

"Increased adrenergic effect of catecholamines"

📖 Source: NLP:liothyronine sodium

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.