Epinephrine

Should not be used concomitantly with albuterol inhalation solution.

Reports of myocardial ischemia, myocardial infarction, and ventricular arrhythmias with concomitant use during nasal surgery. Avoid use of additional vasoconstrictor agents with cocaine hydrochloride nasal solution.

Do not use esmolol to control tachycardia in patients receiving epinephrine due to risk of reducing cardiac contractility in presence of high systemic vascular resistance.

Both drugs are direct cardiac stimulants; combined effects may induce serious arrhythmias upon simultaneous administration.

Should not be used concomitantly with levalbuterol tartrate due to risk of deleterious cardiovascular effects.

Do not use epinephrine to counteract circulatory collapse from phenothiazines; reversal of pressor effects may cause further blood pressure lowering.

Epinephrine should NOT be used to treat hypotension associated with promethazine overdose due to reversal of vasopressor effect.

Epinephrine should NOT be used to treat hypotension associated with overdose due to promethazine's potential to reverse epinephrine's vasopressor effect.

Epinephrine should NOT be used to treat hypotension associated with promethazine overdose due to potential reversal of vasopressor effect.

Patients on long-term propranolol therapy may experience uncontrolled hypertension if administered epinephrine due to unopposed alpha-receptor stimulation. Not indicated for propranolol overdose.

Direct-acting sympathomimetic contraindicated; emergency use only with close monitoring and immediate discontinuation of tranylcypromine if necessary.

Direct-acting sympathomimetic drug contraindicated with tranylcypromine. If emergency treatment necessary, discontinue tranylcypromine immediately and monitor closely.

Patients receiving epinephrine with anti-arrhythmics should be observed carefully for development of cardiac arrhythmias.

Potentiate arrhythmogenic effects of epinephrine; observe carefully for cardiac arrhythmias.

Patients with history of anaphylactic reactions may be unresponsive to usual doses of epinephrine while taking beta-blockers.

Patients with history of anaphylaxis may have more severe reactions and may be unresponsive to usual doses of epinephrine during beta-blocker therapy.

Patients with history of severe anaphylactic reactions may be unresponsive to usual doses of epinephrine while taking beta-blockers.

Serious dose-related cardiac arrhythmias may occur if preparations containing vasoconstrictor are used during or after potent inhalation anesthetics.

May result in increased heart rates, possibly arrhythmias, and excessive changes in blood pressure. Metabolized by COMT.

Potentiate arrhythmogenic effects of epinephrine; observe carefully for cardiac arrhythmias.

Chlorpheniramine potentiates the effects of epinephrine.

Potentiates pressor effects of epinephrine.

Reports of myocardial ischemia, myocardial infarction, and ventricular arrhythmias with concomitant use during nasal surgery. Avoid use; if unavoidable, prolonged vital sign and ECG monitoring required.

Anesthetic that potentiates arrhythmogenic effects of epinephrine.

Cardiac glycosides potentiate arrhythmogenic effects of epinephrine.

Diphenhydramine potentiates the effects of epinephrine.

Patients receiving epinephrine with diuretics should be observed carefully for development of cardiac arrhythmias.

Concomitant use may result in severe hypertension.

Potentiates pressor effects of epinephrine.

COMT inhibitor that potentiates pressor effects of epinephrine.

Ergot alkaloids may reverse the pressor effects of epinephrine.

Epinephrine may antagonize neuronal blockade, decreasing antihypertensive effect and requiring increased dosage.

Halogenated hydrocarbon anesthetic that potentiates arrhythmogenic effects of epinephrine.

May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.

Patients taking labetalol may be unresponsive to usual epinephrine doses for treating allergic reactions, particularly those with history of severe anaphylactic reactions.

Patients on beta-blockers with history of severe anaphylactic reaction may be unresponsive to usual doses of epinephrine used to treat allergic reaction.

Concomitant use may potentiate sympathomimetic effects and cause deleterious cardiovascular effects. Should be avoided or used with caution.

May potentiate effect and cause deleterious cardiovascular effects. Avoid concomitant use; if additional adrenergic drugs needed, use with caution.

Potentiates the effects of epinephrine.

Administration of lidocaine with epinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe prolonged hypertension.

Thyroid hormones increase adrenergic effect of catecholamines. May increase risk of precipitating coronary insufficiency, especially in patients with coronary artery disease.

Potentiate the effects of epinephrine, may cause serious hypertension.

Serious dose-related cardiac arrhythmias may occur if preparations containing vasoconstrictor epinephrine are used during or following potent inhalation anesthetics.

Serious dose-related cardiac arrhythmias may occur with potent inhalation anesthetics. Severe, prolonged hypertension with monoamine oxidase inhibitors or tricyclic antidepressants.

Local anesthetic solutions containing Epinephrine may produce severe, prolonged hypertension in patients receiving tricyclic antidepressants or monoamine oxidase inhibitors; serious cardiac arrhythmias may occur with potent inhalation anesthetics.

Patients may be unresponsive to usual doses of epinephrine used to treat allergic reactions while taking beta-blockers.

Patients may be unresponsive to usual doses of epinephrine used to treat allergic reactions when taking beta-blockers.

Patients may be unresponsive to usual doses of epinephrine used to treat allergic reactions while taking metoprolol.

Patients taking metoprolol with history of severe anaphylactic reactions may be unresponsive to usual doses of epinephrine used to treat allergic reactions.

Concomitant use may be associated with paroxysmal hypertension and possible arrhythmia due to norepinephrine reuptake inhibition.

Potentiate pressor effects of epinephrine.

Patients taking nadolol with history of severe anaphylactic reactions may be unresponsive to usual doses of epinephrine used to treat allergic reactions.

Vasodilator that antagonizes pressor effects of epinephrine.

Potentiates pressor effects of epinephrine.

May produce exaggerated hypotensive response and tachycardia due to alpha- and beta-adrenergic receptor stimulation.

Alpha-adrenergic blocking drugs antagonize the vasoconstricting and hypertensive effects of epinephrine.

Patients with history of severe anaphylactic reactions may be unresponsive to usual epinephrine doses and more reactive to repeated allergen challenge.

Beta-blocker that potentiates pressor effects and potentiates arrhythmogenic effects of epinephrine.

Potentiates arrhythmogenic effects of epinephrine.

Epinephrine administered with sevoflurane may increase the risk of ventricular arrhythmias. Monitor electrocardiogram and blood pressure.

Potentiate arrhythmogenic effects of epinephrine; observe carefully for cardiac arrhythmias.

Patients may be unresponsive to usual doses of epinephrine used to treat anaphylactic reactions.

Injectable epinephrine interaction noted; see Precautions section regarding anaphylaxis management.

Serious dose-related cardiac arrhythmias may occur if preparations containing epinephrine are used during or following potent inhalation anesthetics.

Tripelennamine potentiates the effects of epinephrine.

Additive effects possible when epinephrine is administered with other sympathomimetic agents.

Amitriptyline given with sympathomimetic drugs including epinephrine may have interaction; refer to complete label for details.

Potentiate hypokalemic effects of epinephrine.

Antihistamine that may potentiate the effects of epinephrine.

Sympathomimetic that may reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

May reduce glucose-lowering effect of glipizide, leading to worsening glycemic control; monitor closely.

Tricyclic antidepressant that may potentiate the effects of epinephrine.

Sympathomimetic agent that may decrease the blood glucose lowering effect. Dose adjustment and increased glucose monitoring required.

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Sympathomimetic agent that may decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Sympathomimetic agent that may decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

May decrease blood glucose lowering effect of insulin detemir. Dosage increases and increased glucose monitoring may be required.

Sympathomimetic agent that may decrease the blood glucose lowering effect. Dose increases and increased glucose monitoring may be required.

Sympathomimetic agent that may decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Sympathomimetic agent that may decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Sympathomimetic agent may decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Sympathomimetic agent that may decrease blood glucose lowering effect; dose adjustment and glucose monitoring may be required.

May decrease blood glucose lowering effect of Awiqli. Dose increases and increased glucose monitoring may be required.

Sympathomimetic agent that may decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.

Sympathomimetic agent that may decrease blood glucose lowering effect. Dose increases and increased glucose monitoring may be required.

Concomitant use should be avoided due to potential deleterious cardiovascular effects from potentiation of sympathomimetic activity.

Levothyroxine sodium may potentiate the effects of epinephrine.

Counter the pressor effects of epinephrine.

Close supervision and careful adjustment of dosages required when epinephrine combined with local anesthetics is given with protriptyline.

Potentiates hypokalemic effects of epinephrine.

Local anesthetics containing epinephrine may have potentiated effects when used with trimipramine; particular care should be exercised.

Tricyclic antidepressants potentiate catecholamine effects. Local anesthetics containing epinephrine require particular care when used with trimipramine maleate.

Similar to isoflurane, desflurane does not predispose to premature ventricular arrhythmias in the presence of exogenously infused epinephrine.

Phentolamine mesylate administration did not affect the pharmacokinetics of epinephrine.

Injectable epinephrine interaction noted; see Precautions section for anaphylaxis guidance.