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Does Epinephrine Interact with Tranylcypromine?

Epinephrine and Tranylcypromine have a contraindicated drug interaction according to U.S. FDA drug labeling data. Direct-acting sympathomimetic contraindicated; emergency use only with close monitoring and immediate discontinuation of tranylcypromine if necessary. The mechanism involves hypertensive reaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Epinephrine Class
alpha-Adrenergic Agonist
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Epinephrine and Tranylcypromine occurs because hypertensive reaction. Clinically, this means direct-acting sympathomimetic contraindicated; emergency use only with close monitoring and immediate discontinuation of tranylcypromine if necessary. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Epinephrine and your doctor is considering prescribing Tranylcypromine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Epinephrine(Adrenalin)+💊 Tranylcypromine(Parnate)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
alpha-Adrenergic Agonist
Drug B class
—
Source
NLP:tranylcypromine

What this means in plain English

Direct-acting sympathomimetic contraindicated; emergency use only with close monitoring and immediate discontinuation of tranylcypromine if necessary.

About Epinephrine and Tranylcypromine

Epinephrine is an alpha-Adrenergic Agonist. You may recognize them by the brand names Adrenalin and Parnate. Epinephrine is given by intramuscular injection, whereas Tranylcypromine is taken by mouth. Tranylcypromine additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Hypertensive reaction"

📖 Source: NLP:tranylcypromine

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.