Does Eribulin Mesylate Interact with Rifampin?
Eribulin Mesylate and Rifampin have a minor drug interaction according to U.S. FDA drug labeling data. No clinically meaningful differences in eribulin mesylate exposure observed when administered with rifampin, a CYP3A4 inducer. The mechanism involves cyp3a4 induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Rifampin Class
- Rifamycin Antibacterial
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Eribulin Mesylate and Rifampin occurs because cyp3a4 induction. Clinically, this means no clinically meaningful differences in eribulin mesylate exposure observed when administered with rifampin, a cyp3a4 inducer. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Eribulin Mesylate and your doctor is considering prescribing Rifampin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider