Does Estrogens Interact with Levothyroxine And Liothyronine?
Estrogens and Levothyroxine And Liothyronine have a moderate drug interaction according to U.S. FDA drug labeling data. Estrogens increase serum thyroxine-binding globulin, potentially decreasing free levothyroxine. Patients without functioning thyroid gland may require increased thyroid dose. The mechanism involves increases serum thyroxine-binding globulin. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Levothyroxine And Liothyronine Class
- l-Triiodothyronine
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Estrogens and Levothyroxine And Liothyronine occurs because increases serum thyroxine-binding globulin. Clinically, this means estrogens increase serum thyroxine-binding globulin, potentially decreasing free levothyroxine. patients without functioning thyroid gland may require increased thyroid dose. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Estrogens and your doctor is considering prescribing Levothyroxine And Liothyronine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider