Does Ethiodized Oil Interact with Radioactive Iodine I 131 And I 123?
Ethiodized Oil and Radioactive Iodine I 131 And I 123 have a major drug interaction according to U.S. FDA drug labeling data. Ethiodized oil interferes with radioactive iodine uptake by the thyroid for several weeks to months and may reduce effectiveness of iodine 131 treatment. The mechanism involves interference with radioactive iodine uptake by thyroid tissue. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Ethiodized Oil Class
- Radiographic Contrast Agent
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Ethiodized Oil and Radioactive Iodine I 131 And I 123 occurs because interference with radioactive iodine uptake by thyroid tissue. Clinically, this means ethiodized oil interferes with radioactive iodine uptake by the thyroid for several weeks to months and may reduce effectiveness of iodine 131 treatment. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Ethiodized Oil and your doctor is considering prescribing Radioactive Iodine I 131 And I 123 (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider