Does Etravirine Interact with Dolutegravir Sodium?
Etravirine and Dolutegravir Sodium have a major drug interaction according to U.S. FDA drug labeling data. Etravirine significantly reduces plasma concentrations of dolutegravir, reducing therapeutic effect; coadministration with lopinavir/ritonavir, darunavir/ritonavir, or atazanavir/ritonavir may mitigate this effect. The mechanism involves enzyme induction reducing dolutegravir exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Etravirine Class
- Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Etravirine and Dolutegravir Sodium occurs because enzyme induction reducing dolutegravir exposure. Clinically, this means etravirine significantly reduces plasma concentrations of dolutegravir, reducing therapeutic effect; coadministration with lopinavir/ritonavir, darunavir/ritonavir, or atazanavir/ritonavir may mitigate this effect. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Etravirine and your doctor is considering prescribing Dolutegravir Sodium (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider