Does Famotidine Interact with Dasatinib?
CDI records a contraindicated classification for Famotidine and Dasatinib. The stored summary is: Famotidine reduces gastric acidity and may significantly reduce dasatinib absorption, leading to loss of efficacy. The mechanism involves reduced intragastric acidity decreases absorption of drugs dependent on gastric ph. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Famotidine Class
- Histamine-2 Receptor Antagonist
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Reduced intragastric acidity decreases absorption of drugs dependent on gastric pH
What To Tell Your Doctor or Pharmacist
If you are taking Famotidine and your doctor is considering prescribing Dasatinib (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider