Does Fenfluramine Interact with Clobazam?
Fenfluramine and Clobazam have a moderate drug interaction according to U.S. FDA drug labeling data. Coadministration with stiripentol increases fenfluramine plasma concentrations. Dose adjustment required; maximum daily dosage of FINTEPLA is 0.2 mg/kg twice daily (max 17 mg). The mechanism involves inhibition of fenfluramine metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Clobazam Class
- Benzodiazepine
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Fenfluramine and Clobazam occurs because inhibition of fenfluramine metabolism. Clinically, this means coadministration with stiripentol increases fenfluramine plasma concentrations. dose adjustment required; maximum daily dosage of fintepla is 0.2 mg/kg twice daily (max 17 mg). This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Fenfluramine and your doctor is considering prescribing Clobazam (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider