Does Fenofibrate Interact with Bempedoic Acid And Ezetimibe?
Fenofibrate and Bempedoic Acid And Ezetimibe have a moderate drug interaction according to U.S. FDA drug labeling data. Both fenofibrate and ezetimibe may increase cholesterol excretion into bile, leading to cholelithiasis. Monitor for cholelithiasis; consider gallbladder studies if suspected. The mechanism involves increased cholesterol excretion into bile. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Fenofibrate Class
- Peroxisome Proliferator Receptor alpha Agonist
- Bempedoic Acid And Ezetimibe Class
- Adenosine Triphosphate-Citrate Lyase Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Fenofibrate and Bempedoic Acid And Ezetimibe occurs because increased cholesterol excretion into bile. Clinically, this means both fenofibrate and ezetimibe may increase cholesterol excretion into bile, leading to cholelithiasis. monitor for cholelithiasis; consider gallbladder studies if suspected. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Fenofibrate and your doctor is considering prescribing Bempedoic Acid And Ezetimibe (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider