Does Fenofibric Acid Interact with Colchicine?
CDI records a major classification for Fenofibric Acid and Colchicine. The stored summary is: Cases of myopathy and rhabdomyolysis reported with concomitant use. Monitor patients for signs and symptoms of myopathy during initiation and dosage titration of colchicine. The mechanism involves increased myopathy and rhabdomyolysis risk. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Fenofibric Acid Class
- Peroxisome Proliferator Receptor alpha Agonist
- Colchicine Class
- Alkaloid
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased myopathy and rhabdomyolysis risk
What To Tell Your Doctor or Pharmacist
If you are taking Fenofibric Acid and your doctor is considering prescribing Colchicine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider